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1ZPZ

Factor XI catalytic domain complexed with N-((R)-1-(4-bromophenyl)ethyl)urea-Asn-Val-Arg-alpha-ketothiazole

Summary for 1ZPZ
Entry DOI10.2210/pdb1zpz/pdb
Related1ZHR
DescriptorCoagulation factor XI, SULFATE ION, N~2~-({[(1R)-1-(4-BROMOPHENYL)ETHYL]AMINO}CARBONYL)ASPARAGINYL-N~1~-{4-{[AMINO(IMINO)METHYL]AMINO}-1-[2,3-DIHYDRO-1,3-THIAZOL-2-YL(HYDROXY)METHYL]BUTYL}VALINAMIDE, ... (4 entities in total)
Functional Keywordsserine protease, covalent inhibitor, clotting, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P03951
Total number of polymer chains1
Total formula weight27579.11
Authors
Lin, J.,Deng, H.,Jin, L.,Prandey, P.,Rynkiewicz, M.J.,Bibbins, F.,Cantin, S.,Quinn, J.,Magee, S.,Gorga, J. (deposition date: 2005-05-18, release date: 2006-05-09, Last modification date: 2023-08-23)
Primary citationLin, J.,Deng, H.,Jin, L.,Prandey, P.,Rynkiewicz, M.J.,Bibbins, F.,Cantin, S.,Quinn, J.,Magee, S.,Gorga, J.
Design, Synthesis and Biological Evaluation of Peptidomimetic FXIa Inhibitors
To be Published,
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

217705

건을2024-03-27부터공개중

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