1ZPZ

Factor XI catalytic domain complexed with N-((R)-1-(4-bromophenyl)ethyl)urea-Asn-Val-Arg-alpha-ketothiazole

Summary for 1ZPZ

• Entry DOI: 10.2210/pdb1zpz/pdb
• Related: 1ZHR
• Descriptor: Coagulation factor XI, SULFATE ION, N~2~-({[(1R)-1-(4-BROMOPHENYL)ETHYL]AMINO}CARBONYL)ASPARAGINYL-N~1~-{4-{[AMINO(IMINO)METHYL]AMINO}-1-[2,3-DIHYDRO-1,3-THIAZOL-2-YL(HYDROXY)METHYL]BUTYL}VALINAMIDE, ... (4 entities in total)
• Functional Keywords: serine protease, covalent inhibitor, clotting, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P03951
• Total number of polymer chains: 1
• Total formula weight: 27579.11

Authors

Lin, J.,Deng, H.,Jin, L.,Prandey, P.,Rynkiewicz, M.J.,Bibbins, F.,Cantin, S.,Quinn, J.,Magee, S.,Gorga, J. (deposition date: 2005-05-18, release date: 2006-05-09, Last modification date: 2024-10-16)

• Primary citation: Lin, J.,Deng, H.,Jin, L.,Prandey, P.,Rynkiewicz, M.J.,Bibbins, F.,Cantin, S.,Quinn, J.,Magee, S.,Gorga, J.; Design, Synthesis and Biological Evaluation of Peptidomimetic FXIa Inhibitors; To be Published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)