1ZPH

Crystal structure analysis of the minor groove binding quinolinium quaternary salt SN 8315 complexed with CGCGAATTCGCG

1ZPH の概要

• エントリーDOI: 10.2210/pdb1zph/pdb
• 関連するPDBエントリー: 1ZPI
• 分子名称: 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3', MAGNESIUM ION, 1,6-DIMETHYL-4-(4-(4-(1-METHYLPYRIDINIUM-4-YLAMINO)PHENYLCARBAMOYL)PHENYLAMINO)QUINOLINIUM, ... (4 entities in total)
• 機能のキーワード: b-dna, dodecamer, minor groove binding complex, dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7844.82

構造登録者

Adams, A.,Leong, C.,Denny, W.A.,Guss, J.M. (登録日: 2005-05-16, 公開日: 2005-10-11, 最終更新日: 2024-04-03)

主引用文献

Adams, A.,Leong, C.,Denny, W.A.,Guss, J.M.
Structures of two minor-groove-binding quinolinium quaternary salts complexed with d(CGCGAATTCGCG)(2) at 1.6 and 1.8 Angstrom resolution.
Acta Crystallogr.,Sect.D, 61:1348-1353, 2005

PubMed Abstract: The structures of the complexes formed between two anticancer minor-groove-binding quinolinium quaternary salts and the dodecamer d(CGCGAATTCGCG)(2) have been refined to resolutions of 1.6 and 1.8 Angstrom. The complexes crystallized in space group P2(1)2(1)2(1) and the structures are isomorphous with previously solved dodecamer structures. The ligands both bind in the central AT region of the minor groove and although the crystallization conditions and structures of the ligands are very similar, they bind in opposing orientations. The structures are compared with two previously published structures of quinolinium quaternary salts, refined at 2.5 Angstrom resolution, complexed with d(CGCGAATTCGCG)(2) and an e(6)G-modified DNA.

PubMed: 16204886
DOI: 10.1107/S0907444905022997

実験手法

X-RAY DIFFRACTION (1.8 Å)