1ZOQ

IRF3-CBP complex

Summary for 1ZOQ

• Entry DOI: 10.2210/pdb1zoq/pdb
• Descriptor: Interferon regulatory factor 3, CREB-binding protein (3 entities in total)
• Functional Keywords: transcription regulation, transferase, transcription-transferase complex, transcription/transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: Q14653 Q92793
• Total number of polymer chains: 4
• Total formula weight: 52848.43

Authors

Qin, B.,Lin, K. (deposition date: 2005-05-13, release date: 2006-03-21, Last modification date: 2024-02-14)

Primary citation

Qin, B.Y.,Liu, C.,Srinath, H.,Lam, S.S.,Correia, J.J.,Derynck, R.,Lin, K.
Crystal structure of IRF-3 in complex with CBP.
Structure, 13:1269-1277, 2005

PubMed Abstract: Interferon regulatory factor (IRF) 3 plays a critical role in triggering the activation of interferon antiviral genes. The structure of IRF-3 in association with the CBP/p300 coactivator by in this issue of Structure illuminates the mechanism of IRF activation and the structural flexibilities inherent in CBP/p300.

PubMed: 16154077
DOI: 10.1016/j.str.2005.06.011

Experimental method

X-RAY DIFFRACTION (2.37 Å)