1ZM0

Crystal Structure of the Carboxyl Terminal PH Domain of Pleckstrin To 2.1 Angstroms

1ZM0 の概要

• エントリーDOI: 10.2210/pdb1zm0/pdb
• 関連するPDBエントリー: 1XXO
• 分子名称: Pleckstrin (2 entities in total)
• 機能のキーワード: ph domain, beta sandwich, pleckstrin, lipid binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 26041.64

構造登録者

Jackson, S.G.,Zhang, Y.,Zhang, K.,Summerfield, R.,Haslam, R.J.,Junop, M.S. (登録日: 2005-05-09, 公開日: 2006-02-28, 最終更新日: 2024-02-14)

主引用文献

Jackson, S.G.,Zhang, Y.,Bao, X.,Zhang, K.,Summerfield, R.,Haslam, R.J.,Junop, M.S.
Structure of the carboxy-terminal PH domain of pleckstrin at 2.1 Angstroms.
Acta Crystallogr.,Sect.D, 62:324-330, 2006

PubMed Abstract: Pleckstrin is an important intracellular protein involved in the phosphoinositide-signalling pathways of platelet activation. This protein contains both N- and C-terminal pleckstrin-homology (PH) domains (N-PH and C-PH). The crystal structure of C-PH was solved by molecular replacement and refined at 2.1 Angstroms resolution. Two molecules were observed within the asymmetric unit and it is proposed that the resulting dimer interface could contribute to the previously observed oligomerization of pleckstrin in resting platelets. Structural comparisons between the phosphoinositide-binding loops of the C-PH crystal structure and the PH domains of DAPP1 and TAPP1, the N-terminal PH domain of pleckstrin and a recently described solution structure of C-PH are presented and discussed.

PubMed: 16510979
DOI: 10.1107/S0907444905043179

実験手法

X-RAY DIFFRACTION (2.1 Å)