Summary for 1ZKN
| Entry DOI | 10.2210/pdb1zkn/pdb |
| Related | 1RKO |
| Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
| Functional Keywords | protein-inhibitor complex, inhibitor selectivity, hydrolase |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm (By similarity): Q08499 |
| Total number of polymer chains | 4 |
| Total formula weight | 155274.74 |
| Authors | Huai, Q.,Liu, Y.,Francis, S.H.,Corbin, J.D.,Ke, H. (deposition date: 2005-05-03, release date: 2005-05-17, Last modification date: 2024-04-03) |
| Primary citation | Huai, Q.,Liu, Y.,Francis, S.H.,Corbin, J.D.,Ke, H. Crystal Structures of Phosphodiesterases 4 and 5 in Complex with Inhibitor 3-Isobutyl-1-Methylxanthine Suggest a Conformation Determinant of Inhibitor Selectivity J.Biol.Chem., 279:13095-13101, 2004 Cited by PubMed: 14668322DOI: 10.1074/jbc.M311556200 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report
