1ZHU

DNA (5'-D(*CP*AP*AP*TP*GP*CP*AP*AP*TP*G)-3'), NMR, 10 STRUCTURES

Summary for 1ZHU

• Entry DOI: 10.2210/pdb1zhu/pdb
• Descriptor: DNA (5'-D(*CP*AP*AP*TP*GP*CP*AP*AP*TP*G)-3') (1 entity in total)
• Functional Keywords: dna hairpin, ga mismatch, single residue loop, triplet diseases, dna
• Total number of polymer chains: 1
• Total formula weight: 3053.03

Authors

Zhu, L.,Chou, S.-H.,Xu, J.,Reid, B.R. (deposition date: 1996-01-24, release date: 1996-07-11, Last modification date: 2024-05-22)

Primary citation

Zhu, L.,Chou, S.H.,Xu, J.,Reid, B.R.
Structure of a single-cytidine hairpin loop formed by the DNA triplet GCA.
Nat.Struct.Biol., 2:1012-1017, 1995

PubMed Abstract: In certain contexts the DNA triplet GGA, when juxtaposed on opposite strands of a DNA duplex, shows the unusual property of pairing with itself in an antiparallel orientation to form the (GGA)2 motif. In this motif the central guanines do not pair but intercalate and stack between sheared G.A pairs. Similar studies with GCA triplets reveal that they do not form analogous paired (GCA)2 motifs but instead strongly promote formation of a hairpin, the structure of which is now reported here. The GCA hairpin loop consists of a single cytidine residue closed by a sheared G.A pair and this structure is discussed in the context of triplet expansions in triplet-repeat diseases.

PubMed: 7583654
DOI: 10.1038/nsb1195-1012

Experimental method

SOLUTION NMR