1ZH1

Structure of the zinc-binding domain of HCV NS5A

1ZH1 の概要

• エントリーDOI: 10.2210/pdb1zh1/pdb
• 分子名称: non-structural polyprotein, ZINC ION (3 entities in total)
• 機能のキーワード: hcv, nonstructural protein 5a, ns5a, domain i, metal binding protein
• 由来する生物種: Hepatitis C virus
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): Q9WMX2
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36147.79

構造登録者

Tellinghuisen, T.L.,Marcotrigiano, J.,Rice, C.M. (登録日: 2005-04-22, 公開日: 2005-05-24, 最終更新日: 2011-07-13)

• 主引用文献: Tellinghuisen, T.L.,Marcotrigiano, J.,Rice, C.M.; Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase.; Nature, 435:374-379, 2005; PubMed: 15902263; DOI: 10.1038/nature03580

実験手法

X-RAY DIFFRACTION (2.5 Å)