1ZGC
Crystal Structure of Torpedo Californica Acetylcholinesterase in Complex With an (RS)-Tacrine(10)-Hupyridone Inhibitor.
Summary for 1ZGC
Entry DOI | 10.2210/pdb1zgc/pdb |
Related | 1ZGB |
Descriptor | Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose, (5S)-5-{[10-(1,2,3,4-TETRAHYDROACRIDIN-9-YLAMINO)DECYL]AMINO}-5,6,7,8-TETRAHYDROQUINOLIN-2(1H)-ONE, ... (4 entities in total) |
Functional Keywords | serine-hydrolase, protein-inhibitor complex, enantiomeric selectivity, israel structural proteomics center, ispc, structural genomics, hydrolase |
Biological source | Torpedo californica (Pacific electric ray) |
Cellular location | Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058 |
Total number of polymer chains | 2 |
Total formula weight | 124757.66 |
Authors | Haviv, H.,Wong, D.M.,Greenblatt, H.M.,Carlier, P.R.,Pang, Y.P.,Silman, I.,Sussman, J.L.,Israel Structural Proteomics Center (ISPC) (deposition date: 2005-04-21, release date: 2005-08-16, Last modification date: 2020-07-29) |
Primary citation | Haviv, H.,Wong, D.M.,Greenblatt, H.M.,Carlier, P.R.,Pang, Y.P.,Silman, I.,Sussman, J.L. Crystal Packing Mediates Enantioselective Ligand Recognition at the Peripheral Site of Acetylcholinesterase J.Am.Chem.Soc., 127:11029-11036, 2005 Cited by PubMed: 16076210DOI: 10.1021/ja051765f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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