1ZGC

Crystal Structure of Torpedo Californica Acetylcholinesterase in Complex With an (RS)-Tacrine(10)-Hupyridone Inhibitor.

1ZGC の概要

• エントリーDOI: 10.2210/pdb1zgc/pdb
• 関連するPDBエントリー: 1ZGB
• 分子名称: Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose, (5S)-5-{[10-(1,2,3,4-TETRAHYDROACRIDIN-9-YLAMINO)DECYL]AMINO}-5,6,7,8-TETRAHYDROQUINOLIN-2(1H)-ONE, ... (4 entities in total)
• 機能のキーワード: serine-hydrolase, protein-inhibitor complex, enantiomeric selectivity, israel structural proteomics center, ispc, structural genomics, hydrolase
• 由来する生物種: Torpedo californica (Pacific electric ray)
• 細胞内の位置: Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 124757.66

構造登録者

Haviv, H.,Wong, D.M.,Greenblatt, H.M.,Carlier, P.R.,Pang, Y.P.,Silman, I.,Sussman, J.L.,Israel Structural Proteomics Center (ISPC) (登録日: 2005-04-21, 公開日: 2005-08-16, 最終更新日: 2020-07-29)

• 主引用文献: Haviv, H.,Wong, D.M.,Greenblatt, H.M.,Carlier, P.R.,Pang, Y.P.,Silman, I.,Sussman, J.L.; Crystal Packing Mediates Enantioselective Ligand Recognition at the Peripheral Site of Acetylcholinesterase; J.Am.Chem.Soc., 127:11029-11036, 2005; PubMed: 16076210; DOI: 10.1021/ja051765f

実験手法

X-RAY DIFFRACTION (2.1 Å)