1ZGB

Crystal Structure of Torpedo Californica Acetylcholinesterase in Complex With an (R)-Tacrine(10)-Hupyridone Inhibitor.

Summary for 1ZGB

• Entry DOI: 10.2210/pdb1zgb/pdb
• Related: 1ZGC
• Descriptor: Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose, (5R)-5-{[10-(1,2,3,4-TETRAHYDROACRIDIN-9-YLAMINO)DECYL]AMINO}-5,6,7,8-TETRAHYDROQUINOLIN-2(1H)-ONE, ... (4 entities in total)
• Functional Keywords: serine-hydrolase, protein-inhibitor complex, enantiomeric selectivity, israel structural proteomics center, ispc, structural genomics, hydrolase
• Biological source: Torpedo californica (Pacific electric ray)
• Cellular location: Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058
• Total number of polymer chains: 1
• Total formula weight: 62268.22

Authors

Haviv, H.,Wong, D.M.,Greenblatt, H.M.,Carlier, P.R.,Pang, Y.P.,Silman, I.,Sussman, J.L.,Israel Structural Proteomics Center (ISPC) (deposition date: 2005-04-21, release date: 2005-08-16, Last modification date: 2020-07-29)

• Primary citation: Haviv, H.,Wong, D.M.,Greenblatt, H.M.,Carlier, P.R.,Pang, Y.P.,Silman, I.,Sussman, J.L.; Crystal Packing Mediates Enantioselective Ligand Recognition at the Peripheral Site of Acetylcholinesterase; J.Am.Chem.Soc., 127:11029-11036, 2005; PubMed: 16076210; DOI: 10.1021/ja051765f

Experimental method

X-RAY DIFFRACTION (2.3 Å)