1ZCM

Human calpain protease core inhibited by ZLLYCH2F

Summary for 1ZCM

DescriptorCalpain 1, large [catalytic] subunit, CALCIUM ION, N-[(BENZYLOXY)CARBONYL]LEUCYL-N~1~-[3-FLUORO-1-(4-HYDROXYBENZYL)-2-OXOPROPYL]LEUCINAMIDE, ... (4 entities in total)
Functional Keywordscalcium binding, hydrolase, protease, thiol protease
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm  P07384
Total number of polymer chains1
Total molecular weight37001.79
Authors
Li, Q.,Hanzlik, R.P.,Weaver, R.F.,Schonbrunn, E. (deposition date: 2005-04-12, release date: 2006-01-31, Last modification date: 2017-10-11)
Primary citation
Li, Q.,Hanzlik, R.P.,Weaver, R.F.,Schonbrunn, E.
Molecular mode of action of a covalently inhibiting peptidomimetic on the human calpain protease core
Biochemistry, 45:701-708, 2006
PubMed: 16411745 (PDB entries with the same primary citation)
DOI: 10.1021/bi052077b
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.225130.6%2.6%4.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1zcm
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Molmil generated image of 1zcm
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Molmil generated image of 1zcm
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