1Z8I
Crystal structure of the thrombin mutant G193A bound to PPACK
Summary for 1Z8I
Entry DOI | 10.2210/pdb1z8i/pdb |
Related | 1Z8J |
Related PRD ID | PRD_000020 |
Descriptor | Thrombin light chain, Thrombin heavy chain, ZINC ION, ... (7 entities in total) |
Functional Keywords | serine protease, oxyanion hole, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 |
Total number of polymer chains | 2 |
Total formula weight | 35223.02 |
Authors | Bobofchak, K.M.,Pineda, A.O.,Mathews, F.S.,Di Cera, E. (deposition date: 2005-03-30, release date: 2005-05-17, Last modification date: 2024-03-13) |
Primary citation | Bobofchak, K.M.,Pineda, A.O.,Mathews, F.S.,Di Cera, E. Energetic and structural consequences of perturbing Gly-193 in the oxyanion hole of serine proteases J.Biol.Chem., 280:25644-25650, 2005 Cited by PubMed: 15890651DOI: 10.1074/jbc.M503499200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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