1Z68

Crystal Structure Of Human Fibroblast Activation Protein alpha

Summary for 1Z68

• Entry DOI: 10.2210/pdb1z68/pdb
• Descriptor: fibroblast activation protein, alpha subunit, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: seprase, fibroblast activation protein alpha, fapalpha, dipeptidylpeptidase, s9b, integral membrane serine protease, lyase
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Single-pass type II membrane protein: Q12884
• Total number of polymer chains: 2
• Total formula weight: 169170.11

Authors

Aertgeerts, K.,Levin, I.,Shi, L.,Prasad, G.S.,Zhang, Y.,Kraus, M.L.,Salakian, S.,Snell, G.P.,Sridhar, V.,Wijnands, R.,Tennant, M.G. (deposition date: 2005-03-21, release date: 2005-04-12, Last modification date: 2023-08-23)

• Primary citation: Aertgeerts, K.,Levin, I.,Shi, L.,Snell, G.P.,Jennings, A.,Prasad, G.S.,Zhang, Y.,Kraus, M.L.,Salakian, S.,Sridhar, V.,Wijnands, R.,Tennant, M.G.; Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha.; J.Biol.Chem., 280:19441-19444, 2005; PubMed: 15809306; DOI: 10.1074/jbc.C500092200

Experimental method

X-RAY DIFFRACTION (2.6 Å)