1Z3S

Angiopoietin-2 Receptor Binding Domain

Summary for 1Z3S

• Entry DOI: 10.2210/pdb1z3s/pdb
• Related: 1Z3U
• Descriptor: Angiopoietin-2, CALCIUM ION (3 entities in total)
• Functional Keywords: angiogenesis, tie2 binding, signaling protein
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: O15123
• Total number of polymer chains: 2
• Total formula weight: 49879.53

Authors

Barton, W.A.,Tzvetkova, D.,Nikolov, D.B. (deposition date: 2005-03-14, release date: 2005-07-12, Last modification date: 2024-10-30)

Primary citation

Barton, W.A.,Tzvetkova, D.,Nikolov, D.B.
Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition.
Structure, 13:825-832, 2005

PubMed Abstract: The angiopoietins comprise a small class of secreted glycoproteins that play crucial roles in the maturation and maintenance of the mammalian vascular and lymphatic systems. They exert their effects through a member of the tyrosine kinase receptor family, Tie2. Angiopoietin/Tie2 signaling is unique among tyrosine kinase receptor-ligand systems in that distinct angiopoietin ligands, although highly homologous, can function as agonists or antagonists in a context-dependent manner. In an effort to understand this molecular dichotomy, we have crystallized and determined the 2.4 A crystal structure of the Angiopoietin-2 (Ang2) receptor binding region. The structure reveals a fibrinogen fold with a unique C-terminal P domain. Conservation analysis and structure-based mutagenesis identify a groove on the Ang2 molecular surface that mediates receptor recognition.

PubMed: 15893672
DOI: 10.1016/j.str.2005.03.009

Experimental method

X-RAY DIFFRACTION (2.35 Å)