1Z1I

Crystal structure of native SARS CLpro

1Z1I の概要

• エントリーDOI: 10.2210/pdb1z1i/pdb
• 関連するPDBエントリー: 1Z1J
• 分子名称: 3C-like proteinase (2 entities in total)
• 機能のキーワード: hydrolase
• 由来する生物種: SARS coronavirus
• 細胞内の位置: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity): P59641
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33876.64

構造登録者

Liang, P.H.,Wang, A.H. (登録日: 2005-03-04, 公開日: 2005-11-22, 最終更新日: 2024-03-13)

• 主引用文献: Hsu, M.F.,Kuo, C.J.,Fang, J.M.,Shie, J.J.,Chang, K.T.,Chang, H.C.,Chou, C.C.,Ko, T.P.,Shr, H.L.,Chang, G.G.,Wu, Y.T.,Wang, A.H.,Liang, P.H.; Understanding the maturation process and inhibitor design of SARS-CoV 3CLpro from the crystal structure of C145A in a product-bound form; J.Biol.Chem., 280:31257-31266, 2005; PubMed: 15788388; DOI: 10.1074/jbc.M502577200

実験手法

X-RAY DIFFRACTION (2.8 Å)