1YVZ

Hepatitis C Virus RNA Polymerase Genotype 2a In Complex With Non- Nucleoside Analogue Inhibitor

Summary for 1YVZ

• Entry DOI: 10.2210/pdb1yvz/pdb
• Related: 1YUY 1YVX
• Descriptor: RNA dependent RNA polymerase, SULFATE ION, 3-[(2,4-DICHLOROBENZOYL)(ISOPROPYL)AMINO]-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, ... (4 entities in total)
• Functional Keywords: ns5b polymerase genotype 2a, non-nucleoside inhibitor, viral protein
• Biological source: Hepatitis C virus
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P26660
• Total number of polymer chains: 1
• Total formula weight: 64482.48

Authors

Biswal, B.K.,Cherney, M.M.,Wang, M.,Chan, L.,Yannopoulos, C.G.,Bilimoria, D.,Nicolas, O.,Bedard, J.,James, M.N.G. (deposition date: 2005-02-16, release date: 2005-03-22, Last modification date: 2017-10-11)

• Primary citation: Biswal, B.K.,Cherney, M.M.,Wang, M.,Chan, L.,Yannopoulos, C.G.,Bilimoria, D.,Nicolas, O.,Bedard, J.,James, M.N.G.; Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.; J.Biol.Chem., 280:18202-18210, 2005; PubMed: 15746101; DOI: 10.1074/jbc.M413410200

Experimental method

X-RAY DIFFRACTION (2.2 Å)