1YVX
Hepatitis C Virus RNA Polymerase Genotype 2a In Complex With Non- Nucleoside Analogue Inhibitor
1YVX の概要
エントリーDOI | 10.2210/pdb1yvx/pdb |
関連するPDBエントリー | 1YUY 1YVZ |
分子名称 | RNA dependent RNA polymerase, SULFATE ION, 3-[ISOPROPYL(4-METHYLBENZOYL)AMINO]-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, ... (4 entities in total) |
機能のキーワード | ns5b polymerase genotype 2a, non-nucleoside inhibitor, viral protein |
由来する生物種 | Hepatitis C virus |
細胞内の位置 | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26660 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 64619.74 |
構造登録者 | Biswal, B.K.,Cherney, M.M.,Wang, M.,Chan, L.,Yannopoulos, C.G.,Bilimoria, D.,Nicolas, O.,Bedard, J.,James, M.N.G. (登録日: 2005-02-16, 公開日: 2005-03-22, 最終更新日: 2011-07-13) |
主引用文献 | Biswal, B.K.,Cherney, M.M.,Wang, M.,Chan, L.,Yannopoulos, C.G.,Bilimoria, D.,Nicolas, O.,Bedard, J.,James, M.N.G. Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors. J.Biol.Chem., 280:18202-18210, 2005 Cited by PubMed: 15746101DOI: 10.1074/jbc.M413410200 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
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