1YV2

Hepatitis C virus NS5B RNA-dependent RNA Polymerase genotype 2a

Summary for 1YV2

• Entry DOI: 10.2210/pdb1yv2/pdb
• Related: 1YUY
• Descriptor: RNA dependent RNA polymerase, SULFATE ION, GLYCEROL, ... (4 entities in total)
• Functional Keywords: ns5b polymerase genotype 2a, transferase
• Biological source: Hepatitis C virus
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26660
• Total number of polymer chains: 1
• Total formula weight: 64140.24

Authors

Biswal, B.K.,Cherney, M.M.,Wang, M.,Chan, L.,Yannopoulos, C.G.,Bilimoria, D.,Nicolas, O.,Bedard, J.,James, M.N.G. (deposition date: 2005-02-14, release date: 2005-03-22, Last modification date: 2011-07-13)

• Primary citation: Biswal, B.K.,Cherney, M.M.,Wang, M.,Chan, L.,Yannopoulos, C.G.,Bilimoria, D.,Nicolas, O.,Bedard, J.,James, M.N.G.; Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors; J.Biol.Chem., 280:18202-18210, 2005; PubMed: 15746101; DOI: 10.1074/jbc.M413410200

Experimental method

X-RAY DIFFRACTION (2.5 Å)