1YPY

Crystal Structure of Vaccinia Virus L1 protein

1YPY の概要

• エントリーDOI: 10.2210/pdb1ypy/pdb
• 分子名称: Virion membrane protein (2 entities in total)
• 機能のキーワード: vaccinia virus, orthopox, variola virus, smallpox, l1, viral protein
• 由来する生物種: Vaccinia virus
• 細胞内の位置: Virion membrane ; Single-pass membrane protein : P07612
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 39065.75

構造登録者

Su, H.P.,Garman, S.C.,Allison, T.J.,Fogg, C.,Moss, B.,Garboczi, D.N. (登録日: 2005-01-31, 公開日: 2005-03-01, 最終更新日: 2024-10-09)

主引用文献

Su, H.P.,Garman, S.C.,Allison, T.J.,Fogg, C.,Moss, B.,Garboczi, D.N.
The 1.51-Angstrom structure of the poxvirus L1 protein, a target of potent neutralizing antibodies.
Proc.Natl.Acad.Sci.Usa, 102:4240-4245, 2005

PubMed Abstract: Although eradicated from nature more than two decades ago, the threat of smallpox has reemerged because of concerns over its use as a biological weapon. We present the structure of the poxvirus L1 protein, a molecule that is conserved throughout the poxvirus family and is nearly identical in vaccinia virus and in variola virus, which causes smallpox. L1 is a myristoylated envelope protein that is a potent target for neutralizing antibodies and an important component of current experimental vaccines. The L1 structure reveals a hydrophobic cavity located adjacent to its N terminus. The cavity would be capable of shielding the myristate moiety, which is essential for virion assembly. The structure of L1 is a step in the elucidation of molecular mechanisms common to all poxviruses that may stimulate the design of safer vaccines and new antipoxvirus drugs.

PubMed: 15761054
DOI: 10.1073/pnas.0501103102

実験手法

X-RAY DIFFRACTION (1.51 Å)