1YO4
Solution Structure of the SARS Coronavirus ORF 7a coded X4 protein
Summary for 1YO4
| Entry DOI | 10.2210/pdb1yo4/pdb |
| Descriptor | Hypothetical protein X4 (1 entity in total) |
| Functional Keywords | beta-sandwich, immunoglobulin-like domain, viral protein |
| Biological source | SARS coronavirus |
| Cellular location | Virion: P59635 |
| Total number of polymer chains | 1 |
| Total formula weight | 9909.09 |
| Authors | Haenel, K.,Stangler, T.,Stoldt, M.,Willbold, D. (deposition date: 2005-01-26, release date: 2006-01-17, Last modification date: 2024-10-23) |
| Primary citation | Haenel, K.,Stangler, T.,Stoldt, M.,Willbold, D. Solution structure of the X4 protein coded by the SARS related coronavirus reveals an immunoglobulin like fold and suggests a binding activity to integrin I domains. J.Biomed.Sci., 13:281-293, 2006 Cited by PubMed Abstract: The SARS related Coronavirus genome contains a variety of novel accessory genes. One of these, called ORF7a or ORF8, code for a protein, known as 7a, U122 or X4. We set out to determine the three-dimensional structure of the soluble ectodomain of this type-I transmembrane protein by nuclear magnetic resonance spectroscopy. The fold of the protein is the first member of a further variation of the immunoglobulin like beta-sandwich fold. Because X4 does not reveal significant sequence homologies to proteins in the data bases, we carried out a structure based similarity search for proteins with known function. High structural similarity to Dl domains of ICAM-1 and ICAM-2, and common features in amino acid sequence between X4 and ICAM-1, suggest X4 to possess binding activity for the alpha(L) integrin I domain of LFA-1. Further, based on this structure based prediction, potential functions of X4 in virus replication and pathogenesis are discussed. PubMed: 16328780DOI: 10.1007/s11373-005-9043-9 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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