1YO4

Solution Structure of the SARS Coronavirus ORF 7a coded X4 protein

1YO4 の概要

• エントリーDOI: 10.2210/pdb1yo4/pdb
• 分子名称: Hypothetical protein X4 (1 entity in total)
• 機能のキーワード: beta-sandwich, immunoglobulin-like domain, viral protein
• 由来する生物種: SARS coronavirus
• 細胞内の位置: Virion: P59635
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 9909.09

構造登録者

Haenel, K.,Stangler, T.,Stoldt, M.,Willbold, D. (登録日: 2005-01-26, 公開日: 2006-01-17, 最終更新日: 2024-10-23)

主引用文献

Haenel, K.,Stangler, T.,Stoldt, M.,Willbold, D.
Solution structure of the X4 protein coded by the SARS related coronavirus reveals an immunoglobulin like fold and suggests a binding activity to integrin I domains.
J.Biomed.Sci., 13:281-293, 2006

PubMed Abstract: The SARS related Coronavirus genome contains a variety of novel accessory genes. One of these, called ORF7a or ORF8, code for a protein, known as 7a, U122 or X4. We set out to determine the three-dimensional structure of the soluble ectodomain of this type-I transmembrane protein by nuclear magnetic resonance spectroscopy. The fold of the protein is the first member of a further variation of the immunoglobulin like beta-sandwich fold. Because X4 does not reveal significant sequence homologies to proteins in the data bases, we carried out a structure based similarity search for proteins with known function. High structural similarity to Dl domains of ICAM-1 and ICAM-2, and common features in amino acid sequence between X4 and ICAM-1, suggest X4 to possess binding activity for the alpha(L) integrin I domain of LFA-1. Further, based on this structure based prediction, potential functions of X4 in virus replication and pathogenesis are discussed.

PubMed: 16328780
DOI: 10.1007/s11373-005-9043-9

実験手法

SOLUTION NMR