1YMC

THREE-DIMENSIONAL STRUCTURE OF CYANOMET-SULFMYOGLOBIN C

1YMC の概要

• エントリーDOI: 10.2210/pdb1ymc/pdb
• 分子名称: CYANOMET-SULFMYOGLOBIN, SULFATE ION, CYANIDE ION, ... (5 entities in total)
• 機能のキーワード: oxygen transport
• 由来する生物種: Equus caballus (horse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17754.15

構造登録者

Evans, S.V.,Brayer, G.D. (登録日: 1993-09-27, 公開日: 1994-01-31, 最終更新日: 2024-02-14)

主引用文献

Evans, S.V.,Sishta, B.P.,Mauk, A.G.,Brayer, G.D.
Three-dimensional structure of cyanomet-sulfmyoglobin C.
Proc.Natl.Acad.Sci.USA, 91:4723-4726, 1994

PubMed Abstract: The atomic structure of horse heart cyanomet-sulfmyoglobin C has been established by x-ray crystallographic techniques to a resolution of 2.0 A with an R value of 0.129. The protoheme IX prosthetic group of this thermodynamically stable sulfmyoglobin derivative has been converted to a chlorin in which the pyrrole ring bearing the 4-vinyl group is saturated and possesses an exocyclic thiolene ring. This study provides the three-dimensional structure of a protein with an iron-chlorin prosthetic group. The overall conformation of the surrounding polypeptide chain of the modified protein is very similar to that of the native protein. However, the addition of the sulfur atom has caused a distortion of the prosthetic group from that in the native protein to result in the repositioning of the side chains of some residues in the heme pocket.

PubMed: 8197124
DOI: 10.1073/pnas.91.11.4723

実験手法

X-RAY DIFFRACTION (2 Å)