1YDV

TRIOSEPHOSPHATE ISOMERASE (TIM)

Summary for 1YDV

• Entry DOI: 10.2210/pdb1ydv/pdb
• Descriptor: TRIOSEPHOSPHATE ISOMERASE (2 entities in total)
• Functional Keywords: isomerase, glycolysis, gluconeogenesis
• Biological source: Plasmodium falciparum (malaria parasite P. falciparum)
• Total number of polymer chains: 2
• Total formula weight: 55995.48

Authors

Velankar, S.S.,Murthy, M.R.N. (deposition date: 1997-04-24, release date: 1997-10-15, Last modification date: 2024-04-03)

Primary citation

Velanker, S.S.,Ray, S.S.,Gokhale, R.S.,Suma, S.,Balaram, H.,Balaram, P.,Murthy, M.R.
Triosephosphate isomerase from Plasmodium falciparum: the crystal structure provides insights into antimalarial drug design.
Structure, 5:751-761, 1997

PubMed Abstract: Malaria caused by the parasite Plasmodium falciparum is a major public health concern. The parasite lacks a functional tricarboxylic acid cycle, making glycolysis its sole energy source. Although parasite enzymes have been considered as potential antimalarial drug targets, little is known about their structural biology. Here we report the crystal structure of triosephosphate isomerase (TIM) from P. falciparum at 2.2 A resolution.

PubMed: 9261072
DOI: 10.1016/S0969-2126(97)00230-X

Experimental method

X-RAY DIFFRACTION (2.2 Å)