1YDV

TRIOSEPHOSPHATE ISOMERASE (TIM)

1YDV の概要

• エントリーDOI: 10.2210/pdb1ydv/pdb
• 分子名称: TRIOSEPHOSPHATE ISOMERASE (2 entities in total)
• 機能のキーワード: isomerase, glycolysis, gluconeogenesis
• 由来する生物種: Plasmodium falciparum (malaria parasite P. falciparum)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55995.48

構造登録者

Velankar, S.S.,Murthy, M.R.N. (登録日: 1997-04-24, 公開日: 1997-10-15, 最終更新日: 2024-04-03)

主引用文献

Velanker, S.S.,Ray, S.S.,Gokhale, R.S.,Suma, S.,Balaram, H.,Balaram, P.,Murthy, M.R.
Triosephosphate isomerase from Plasmodium falciparum: the crystal structure provides insights into antimalarial drug design.
Structure, 5:751-761, 1997

PubMed Abstract: Malaria caused by the parasite Plasmodium falciparum is a major public health concern. The parasite lacks a functional tricarboxylic acid cycle, making glycolysis its sole energy source. Although parasite enzymes have been considered as potential antimalarial drug targets, little is known about their structural biology. Here we report the crystal structure of triosephosphate isomerase (TIM) from P. falciparum at 2.2 A resolution.

PubMed: 9261072
DOI: 10.1016/S0969-2126(97)00230-X

実験手法

X-RAY DIFFRACTION (2.2 Å)