1Y9H

Methylation of cytosine at C5 in a CpG sequence context causes a conformational switch of a benzo[a]pyrene diol epoxide-N2-guanine adduct in DNA from a minor groove alignment to intercalation with base displacement

Summary for 1Y9H

• Entry DOI: 10.2210/pdb1y9h/pdb
• Descriptor: 5'-D(*CP*CP*AP*TP*(5CM)P*(BPG)P*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*CP*GP*AP*TP*GP*G)-3', 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE (3 entities in total)
• Functional Keywords: conformational switch, cytosine methylation, p53 mutation hot spot, dna adduct, benzo[a]pyrene, bpde, dna
• Total number of polymer chains: 2
• Total formula weight: 7026.76

Authors

Zhang, N.,Lin, C.,Huang, X.,Kolbanovskiy, A.,Hingerty, B.E.,Amin, S.,Broyde, S.,Geacintov, N.E.,Patel, D.J. (deposition date: 2004-12-15, release date: 2005-03-22, Last modification date: 2024-04-24)

• Primary citation: Zhang, N.,Lin, C.,Huang, X.,Kolbanovskiy, A.,Hingerty, B.E.,Amin, S.,Broyde, S.,Geacintov, N.E.,Patel, D.J.; Methylation of cytosine at C5 in a CpG sequence context causes a conformational switch of a benzo[a]pyrene diol epoxide-N2-guanine adduct in DNA from a minor groove alignment to intercalation with base displacement.; J.Mol.Biol., 346:951-965, 2005; PubMed: 15701509; DOI: 10.1016/j.jmb.2004.12.027

Experimental method

SOLUTION NMR