1Y9H
Methylation of cytosine at C5 in a CpG sequence context causes a conformational switch of a benzo[a]pyrene diol epoxide-N2-guanine adduct in DNA from a minor groove alignment to intercalation with base displacement
1Y9H の概要
エントリーDOI | 10.2210/pdb1y9h/pdb |
分子名称 | 5'-D(*CP*CP*AP*TP*(5CM)P*(BPG)P*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*CP*GP*AP*TP*GP*G)-3', 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE (3 entities in total) |
機能のキーワード | conformational switch, cytosine methylation, p53 mutation hot spot, dna adduct, benzo[a]pyrene, bpde, dna |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 7026.76 |
構造登録者 | Zhang, N.,Lin, C.,Huang, X.,Kolbanovskiy, A.,Hingerty, B.E.,Amin, S.,Broyde, S.,Geacintov, N.E.,Patel, D.J. (登録日: 2004-12-15, 公開日: 2005-03-22, 最終更新日: 2024-04-24) |
主引用文献 | Zhang, N.,Lin, C.,Huang, X.,Kolbanovskiy, A.,Hingerty, B.E.,Amin, S.,Broyde, S.,Geacintov, N.E.,Patel, D.J. Methylation of cytosine at C5 in a CpG sequence context causes a conformational switch of a benzo[a]pyrene diol epoxide-N2-guanine adduct in DNA from a minor groove alignment to intercalation with base displacement. J.Mol.Biol., 346:951-965, 2005 Cited by PubMed: 15701509DOI: 10.1016/j.jmb.2004.12.027 主引用文献が同じPDBエントリー |
実験手法 | SOLUTION NMR |
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