1Y8H

HORSE METHEMOGLOBIN LOW SALT, PH 7.0

1Y8H の概要

• エントリーDOI: 10.2210/pdb1y8h/pdb
• 関連するPDBエントリー: 1JY7 1LFQ 1y8i 1y8k
• 分子名称: Hemoglobin alpha chains, Hemoglobin beta chain, PROTOPORPHYRIN IX CONTAINING FE, ... (4 entities in total)
• 機能のキーワード: aquo methemoglobin, quarternary association, allosteric transition, oxygen storage-transport complex, oxygen storage/transport
• 由来する生物種: Equus caballus (horse); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 64807.06

構造登録者

Sankaranarayanan, R.,Biswal, B.K.,Vijayan, M. (登録日: 2004-12-13, 公開日: 2005-07-26, 最終更新日: 2023-08-23)

主引用文献

Sankaranarayanan, R.,Biswal, B.K.,Vijayan, M.
A new relaxed state in horse methemoglobin characterized by crystallographic studies.
Proteins, 60:547-551, 2005

PubMed Abstract: A new relaxed state has been characterized in the crystals of horse methemoglobin grown at neutral pH at low ionic concentration and their low humidity variants. The crystals provide an example for improvement in X-ray diffraction quality with reduced solvent content. Only the classical R state has been so far observed in liganded horse hemoglobin. The state characterized in the present study lies in between the R state and the R2 state characterized earlier in liganded human hemoglobin. The results presented here, along with those of earlier studies, suggest that relaxed and tense hemoglobin can access ensembles of states.

PubMed: 15887226
DOI: 10.1002/prot.20510

実験手法

X-RAY DIFFRACTION (3.1 Å)