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1Y8D

Dimeric parallel-stranded tetraplex with 3+1 5' G-tetrad interface, single-residue chain reversal loops and GAG triad in the context of A(GGGG) pentad

Summary for 1Y8D
Entry DOI10.2210/pdb1y8d/pdb
Related1EEG 1JJP
Descriptor5'-D(*GP*GP*GP*GP*TP*GP*GP*GP*AP*GP*GP*AP*GP*GP*GP*T)-3' (1 entity in total)
Functional Keywordsdimeric parallel-stranded quadruplex; dna aptamer;hiv-1 integrase inhibitor design; 3+1 g-tetrad; single nucleotide chain reversal loop; gag triad; (a)gggg pentad, dna
Total number of polymer chains2
Total formula weight10280.62
Authors
Phan, A.T.,Kuryavyi, V.V.,Ma, J.-B.,Faure, A.,Andreola, M.-L.,Patel, D.J. (deposition date: 2004-12-11, release date: 2005-02-01, Last modification date: 2022-03-02)
Primary citationPhan, A.T.,Kuryavyi, V.V.,Ma, J.-B.,Faure, A.,Andreola, M.-L.,Patel, D.J.
An interlocked dimeric parallel-stranded DNA quadruplex: A potent inhibitor of HIV-1 integrase
Proc.Natl.Acad.Sci.USA, 102:634-639, 2005
Cited by
PubMed: 15637158
DOI: 10.1073/pnas.0406278102
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation

217705

数据于2024-03-27公开中

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