1Y8D
Dimeric parallel-stranded tetraplex with 3+1 5' G-tetrad interface, single-residue chain reversal loops and GAG triad in the context of A(GGGG) pentad
Summary for 1Y8D
Entry DOI | 10.2210/pdb1y8d/pdb |
Related | 1EEG 1JJP |
Descriptor | 5'-D(*GP*GP*GP*GP*TP*GP*GP*GP*AP*GP*GP*AP*GP*GP*GP*T)-3' (1 entity in total) |
Functional Keywords | dimeric parallel-stranded quadruplex; dna aptamer;hiv-1 integrase inhibitor design; 3+1 g-tetrad; single nucleotide chain reversal loop; gag triad; (a)gggg pentad, dna |
Total number of polymer chains | 2 |
Total formula weight | 10280.62 |
Authors | Phan, A.T.,Kuryavyi, V.V.,Ma, J.-B.,Faure, A.,Andreola, M.-L.,Patel, D.J. (deposition date: 2004-12-11, release date: 2005-02-01, Last modification date: 2024-05-22) |
Primary citation | Phan, A.T.,Kuryavyi, V.V.,Ma, J.-B.,Faure, A.,Andreola, M.-L.,Patel, D.J. An interlocked dimeric parallel-stranded DNA quadruplex: A potent inhibitor of HIV-1 integrase Proc.Natl.Acad.Sci.USA, 102:634-639, 2005 Cited by PubMed: 15637158DOI: 10.1073/pnas.0406278102 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
Download full validation report