1Y75

A new form of catalytically inactive phospholipase A2 with an unusual disulphide bridge Cys 32- Cys 49 reveals recognition for N-acetylglucosmine

1Y75 の概要

• エントリーDOI: 10.2210/pdb1y75/pdb
• 関連するPDBエントリー: 1S6B
• 分子名称: phospholipase A2 isoform 5, phospholipase A2 isoform 6, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: enzyme, activity, molecular association, hydrolase
• 由来する生物種: Naja sagittifera; 詳細
• 細胞内の位置: Secreted: Q5G291 Q5G290
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 26139.60

構造登録者

Jabeen, T.,Singh, N.,Jasti, J.,Singh, R.K.,Sharma, S.,Perbandt, M.,Betzel, C.,Kaur, P.,Srinivasan, A.,Singh, T.P. (登録日: 2004-12-08, 公開日: 2005-05-03, 最終更新日: 2020-07-29)

• 主引用文献: Jabeen, T.,Singh, N.,Singh, R.K.,Jasti, J.,Sharma, S.,Kaur, P.,Srinivasan, A.,Singh, T.P.; Crystal structure of a heterodimer of phospholipase A2 from Naja naja sagittifera at 2.3 A resolution reveals the presence of a new PLA2-like protein with a novel cys 32-Cys 49 disulphide bridge with a bound sugar at the substrate-binding site; Proteins, 62:329-337, 2006; PubMed: 16287060; DOI: 10.1002/prot.20708

実験手法

X-RAY DIFFRACTION (2.3 Å)