1Y2Q

Crystal structure of the editing domain of threonyl-tRNA synthetase from Pyrococcus abyssi

1Y2Q の概要

• エントリーDOI: 10.2210/pdb1y2q/pdb
• 関連するPDBエントリー: 1Y2R
• 分子名称: Threonyl-tRNA synthetase (2 entities in total)
• 機能のキーワード: beta-alpha-beta fold, editing domain, trna-synthetase, ligase
• 由来する生物種: Pyrococcus abyssi
• 細胞内の位置: Cytoplasm: Q9UZ14
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16281.80

構造登録者

Dwivedi, S.,Kruparani, S.P.,Sankaranarayanan, R. (登録日: 2004-11-23, 公開日: 2005-06-14, 最終更新日: 2024-03-13)

主引用文献

Dwivedi, S.,Kruparani, S.P.,Sankaranarayanan, R.
A D-amino acid editing module coupled to the translational apparatus in archaea
Nat.Struct.Mol.Biol., 12:556-557, 2005

PubMed Abstract: We report the crystal structure of an archaea-specific editing domain of threonyl-tRNA synthetase that reveals a marked structural similarity to D-amino acid deacylases found in eubacteria and eukaryotes. The domain can bind D-amino acids despite a low sequence identity to other D-amino acid deacylases. These results together indicate the presence of these deacylases in all three kingdoms of life. This underlines an important role they may have played in enforcing homochirality during translation.

PubMed: 15908961
DOI: 10.1038/nsmb943

実験手法

X-RAY DIFFRACTION (1.95 Å)