1Y2K

Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 3,5-dimethyl-1-(3-nitro-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

Summary for 1Y2K

• Entry DOI: 10.2210/pdb1y2k/pdb
• Related: 1Y2B 1Y2C 1Y2D 1Y2E 1Y2H 1Y2J
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: phosphodiesterase, pde, pde4d, pyrazole, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (By similarity): Q08499
• Total number of polymer chains: 2
• Total formula weight: 82998.96

Authors

Card, G.L.,Blasdel, L.,England, B.P.,Zhang, C.,Suzuki, Y.,Gillette, S.,Fong, D.,Ibrahim, P.N.,Artis, D.R.,Bollag, G.,Milburn, M.V.,Kim, S.-H.,Schlessinger, J.,Zhang, K.Y.J. (deposition date: 2004-11-22, release date: 2005-03-01, Last modification date: 2024-02-14)

• Primary citation: Card, G.L.,Blasdel, L.,England, B.P.,Zhang, C.,Suzuki, Y.,Gillette, S.,Fong, D.,Ibrahim, P.N.,Artis, D.R.,Bollag, G.,Milburn, M.V.,Kim, S.-H.,Schlessinger, J.,Zhang, K.Y.J.; A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design; Nat.Biotechnol., 23:201-207, 2005; PubMed: 15685167; DOI: 10.1038/nbt1059

Experimental method

X-RAY DIFFRACTION (1.36 Å)