1XWV

Structure of the house dust mite allergen Der f 2: Implications for function and molecular basis of IgE cross-reactivity

Summary for 1XWV

• Entry DOI: 10.2210/pdb1xwv/pdb
• Descriptor: Der f II, 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, 3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL, ... (4 entities in total)
• Functional Keywords: beta sheets, allergen
• Biological source: Dermatophagoides farinae (American house dust mite)
• Cellular location: Secreted: Q00855
• Total number of polymer chains: 2
• Total formula weight: 29201.65

Authors

Johannessen, B.R.,Skov, L.K.,Kastrup, J.S.,Kristensen, O.,Bolwig, C.,Larsen, J.N.,Spangfort, M.,Lund, K.,Gajhede, M. (deposition date: 2004-11-02, release date: 2004-12-14, Last modification date: 2024-11-06)

Primary citation

Johannessen, B.R.,Skov, L.K.,Kastrup, J.S.,Kristensen, O.,Bolwig, C.,Larsen, J.N.,Spangfort, M.,Lund, K.,Gajhede, M.
Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity.
Febs Lett., 579:1208-1212, 2005

PubMed Abstract: The X-ray structure of the group 2 major allergen from Dermatophagoides farinae (Der f 2) was determined to 1.83 A resolution. The overall Der f 2 structure comprises a single domain of immunoglobulin fold with two anti-parallel beta-sheets. A large hydrophobic cavity is formed in the interior of Der f 2. Structural comparisons to distantly related proteins suggest a role in lipid binding. Immunoglobulin E (IgE) cross-reactivity between group 2 house dust mite major allergens can be explained by conserved surface areas representing IgE binding epitopes.

PubMed: 15710415
DOI: 10.1016/j.febslet.2004.11.115

Experimental method

X-RAY DIFFRACTION (1.83 Å)