1XT5

Crystal Structure of VCBP3, domain 1, from Branchiostoma floridae

1XT5 の概要

• エントリーDOI: 10.2210/pdb1xt5/pdb
• 分子名称: variable region-containing chitin-binding protein 3, SULFATE ION (3 entities in total)
• 機能のキーワード: innate immunity, vcbp, primordial antigen receptor, florida lancelet, amphioxus, immune system
• 由来する生物種: Branchiostoma floridae (Florida lancelet)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14893.54

構造登録者

Hernandez Prada, J.A.,Haire, R.N.,Cannon, J.P.,Allaire, M.,Jakoncic, J.,Stojanoff, V.,Litman, G.W.,Ostrov, D.A. (登録日: 2004-10-21, 公開日: 2005-10-04, 最終更新日: 2024-11-20)

主引用文献

Haire, R.N.,Allaire, M.,Jakoncic, J.,Stojanoff, V.,Cannon, J.P.,Litman, G.W.,Ostrov, D.A.
Ancient evolutionary origin of diversified variable regions demonstrated by crystal structures of an immune-type receptor in amphioxus.
Nat.Immunol., 7:875-882, 2006

PubMed Abstract: Although the origins of genes encoding the rearranging binding receptors remain obscure, it is predicted that their ancestral forms were nonrearranging immunoglobulin-type domains. Variable region-containing chitin-binding proteins (VCBPs) are diversified immune-type molecules found in amphioxus (Branchiostoma floridae), an invertebrate that diverged early in deuterostome phylogeny. To study the potential evolutionary relationships between VCBPs and vertebrate adaptive immune receptors, we solved the structures of both a single V-type domain (to 1.15 A) and a pair of V-type domains (to 1.85 A) from VCBP3. The deduced structures show integral features of the ancestral variable-region fold as well as unique features of variable-region pairing in molecules that may reflect characteristics of ancestral forms of diversified immune receptors found in modern-day vertebrates.

PubMed: 16799561
DOI: 10.1038/ni1359

実験手法

X-RAY DIFFRACTION (1.15 Å)