1XRW

Solution Structure of a Platinum-Acridine Modified Octamer

Summary for 1XRW

• Entry DOI: 10.2210/pdb1xrw/pdb
• Descriptor: 5'-D(*CP*CP*TP*CP*GP*TP*CP*C)-3', 5'-D(*GP*GP*AP*CP*GP*AP*GP*G)-3', 1-[2-(ACRIDIN-9-YLAMINO)ETHYL]-1,3-DIMETHYLTHIOUREA-PLATINUM(II)-ETHANE-1,2-DIAMINE (3 entities in total)
• Functional Keywords: platinum, acridine, dual binding mode, major groove, unwinding, dna
• Total number of polymer chains: 2
• Total formula weight: 5435.84

Authors

Baruah, H.,Wright, M.W.,Bierbach, U. (deposition date: 2004-10-16, release date: 2005-05-03, Last modification date: 2024-05-01)

• Primary citation: Baruah, H.,Wright, M.W.,Bierbach, U.; Solution Structural Study of a DNA Duplex Containing the Guanine-N7 Adduct Formed by a Cytotoxic Platinum-Acridine Hybrid Agent; Biochemistry, 44:6059-6070, 2005; PubMed: 15835895; DOI: 10.1021/bi050021b

Experimental method

SOLUTION NMR