1XR3

Actinorhodin Polyketide Ketoreductase with NADP and the Inhibitor Isoniazid bound

Summary for 1XR3

Entry DOI	10.2210/pdb1xr3/pdb
Descriptor	ACTINORHODIN POLYKETIDE KETOREDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-(DIAZENYLCARBONYL)PYRIDINE (3 entities in total)
Functional Keywords	protein-inhibitor complex, oxidoreductase
Biological source	Streptomyces coelicolor
Total number of polymer chains	2
Total formula weight	56343.08
Authors	Korman, T.P.,Hill, J.A.,Vu, T.N.,Tsai, S.C. (deposition date: 2004-10-13, release date: 2005-09-27, Last modification date: 2023-08-23)
Primary citation	Korman, T.P.,Hill, J.A.,Vu, T.N.,Tsai, S.C. Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity. Biochemistry, 43:14529-14538, 2004 Cited by PubMed: 15544323 DOI: 10.1021/bi048133a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.71 Å)

Structure validation