1XP9
HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 18
Summary for 1XP9
Entry DOI | 10.2210/pdb1xp9/pdb |
Related | 1XP1 1XP6 1XPC |
Descriptor | Estrogen receptor, (2S,3R)-3-(4-HYDROXYPHENYL)-2-(4-{[(2S)-2-PYRROLIDIN-1-YLPROPYL]OXY}PHENYL)-2,3-DIHYDRO-1,4-BENZOXATHIIN-6-OL (3 entities in total) |
Functional Keywords | nuclear receptor, transcription factor, er-alpha, antagonist, hormone-growth factor receptor complex, hormone/growth factor receptor |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372 |
Total number of polymer chains | 1 |
Total formula weight | 28779.91 |
Authors | Fitzgerald, P.M.D.,Sharma, N. (deposition date: 2004-10-08, release date: 2004-12-07, Last modification date: 2024-02-14) |
Primary citation | Blizzard, T.A.,Dininno, F.,Morgan, J.D.,Chen, H.Y.,Wu, J.Y.,Kim, S.,Chan, W.,Birzin, E.T.,Yang, Y.T.,Pai, L.Y.,Fitzgerald, P.M.,Sharma, N.,Li, Y.,Zhang, Z.,Hayes, E.C.,Dasilva, C.A.,Tang, W.,Rohrer, S.P.,Schaeffer, J.M.,Hammond, M.L. Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers. Bioorg.Med.Chem.Lett., 15:107-113, 2005 Cited by PubMed: 15582421DOI: 10.1016/j.bmcl.2004.10.036 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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