1XP1

HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 15

Summary for 1XP1

Entry DOI	10.2210/pdb1xp1/pdb
Related	1SJ0 1XP6 1XP9 1XPC
Descriptor	Estrogen receptor, (2S,3R)-2-(4-{2-[(3R,4R)-3,4-DIMETHYLPYRROLIDIN-1-YL]ETHOXY}PHENYL)-3-(4-HYDROXYPHENYL)-2,3-DIHYDRO-1,4-BENZOXATHIIN-6- OL (3 entities in total)
Functional Keywords	nuclear receptor, transcription factor, er-alpha, antagonist, hormone-growth factor receptor complex, hormone/growth factor receptor
Biological source	Homo sapiens (human)
Cellular location	Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
Total number of polymer chains	1
Total formula weight	28793.94
Authors	Fitzgerald, P.M.D.,Sharma, N. (deposition date: 2004-10-07, release date: 2004-12-07, Last modification date: 2024-02-14)
Primary citation	Blizzard, T.A.,Dininno, F.,Morgan, J.D.,Chen, H.Y.,Wu, J.Y.,Kim, S.,Chan, W.,Birzin, E.T.,Yang, Y.T.,Pai, L.Y.,Fitzgerald, P.M.,Sharma, N.,Li, Y.,Zhang, Z.,Hayes, E.C.,Dasilva, C.A.,Tang, W.,Rohrer, S.P.,Schaeffer, J.M.,Hammond, M.L. Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers. Bioorg.Med.Chem.Lett., 15:107-113, 2005 Cited by PubMed: 15582421 DOI: 10.1016/j.bmcl.2004.10.036 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation