1XP1

HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 15

1XP1 の概要

• エントリーDOI: 10.2210/pdb1xp1/pdb
• 関連するPDBエントリー: 1SJ0 1XP6 1XP9 1XPC
• 分子名称: Estrogen receptor, (2S,3R)-2-(4-{2-[(3R,4R)-3,4-DIMETHYLPYRROLIDIN-1-YL]ETHOXY}PHENYL)-3-(4-HYDROXYPHENYL)-2,3-DIHYDRO-1,4-BENZOXATHIIN-6- OL (3 entities in total)
• 機能のキーワード: nuclear receptor, transcription factor, er-alpha, antagonist, hormone-growth factor receptor complex, hormone/growth factor receptor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28793.94

構造登録者

Fitzgerald, P.M.D.,Sharma, N. (登録日: 2004-10-07, 公開日: 2004-12-07, 最終更新日: 2024-02-14)

• 主引用文献: Blizzard, T.A.,Dininno, F.,Morgan, J.D.,Chen, H.Y.,Wu, J.Y.,Kim, S.,Chan, W.,Birzin, E.T.,Yang, Y.T.,Pai, L.Y.,Fitzgerald, P.M.,Sharma, N.,Li, Y.,Zhang, Z.,Hayes, E.C.,Dasilva, C.A.,Tang, W.,Rohrer, S.P.,Schaeffer, J.M.,Hammond, M.L.; Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.; Bioorg.Med.Chem.Lett., 15:107-113, 2005; PubMed: 15582421; DOI: 10.1016/j.bmcl.2004.10.036

実験手法

X-RAY DIFFRACTION (1.8 Å)