1XOK
crystal structure of alfalfa mosaic virus RNA 3'UTR in complex with coat protein N terminal peptide
Summary for 1XOK
| Entry DOI | 10.2210/pdb1xok/pdb |
| Descriptor | alfalfa mosaic virus RNA 3' UTR, Coat protein, BROMIDE ION, ... (5 entities in total) |
| Functional Keywords | protein-rna complex, alpha helix, atypical rna duplex, viral protein-rna complex, viral protein/rna |
| Cellular location | Virion (Potential): P24264 |
| Total number of polymer chains | 4 |
| Total formula weight | 18060.80 |
| Authors | Guogas, L.M.,Filman, D.J.,Hogle, J.M.,Gehrke, L. (deposition date: 2004-10-06, release date: 2005-01-04, Last modification date: 2024-02-14) |
| Primary citation | Guogas, L.M.,Filman, D.J.,Hogle, J.M.,Gehrke, L. Cofolding organizes alfalfa mosaic virus RNA and coat protein for replication. Science, 306:2108-2111, 2004 Cited by PubMed Abstract: Alfalfa mosaic virus genomic RNAs are infectious only when the viral coat protein binds to the RNA 3' termini. The crystal structure of an alfalfa mosaic virus RNA-peptide complex reveals that conserved AUGC repeats and Pro-Thr-x-Arg-Ser-x-x-Tyr coat protein amino acids cofold upon interacting. Alternating AUGC residues have opposite orientation, and they base pair in different adjacent duplexes. Localized RNA backbone reversals stabilized by arginine-guanine interactions place the adenosines and guanines in reverse order in the duplex. The results suggest that a uniform, organized 3' conformation, similar to that found on viral RNAs with transfer RNA-like ends, may be essential for replication. PubMed: 15604410DOI: 10.1126/science.1103399 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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