1XOI
Human Liver Glycogen Phosphorylase A complexed with Chloroindoloyl glycine amide
Summary for 1XOI
| Entry DOI | 10.2210/pdb1xoi/pdb |
| Related | 1EM6 1EXV |
| Descriptor | Glycogen phosphorylase, liver form, N-acetyl-beta-D-glucopyranosylamine, PYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total) |
| Functional Keywords | allosteric enzyme, glycogen storage disease, glycosyltransferase, transferase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 195987.00 |
| Authors | Wright, S.W.,Rath, V.L.,Gibbs, E.M.,Treadway, J.L. (deposition date: 2004-10-06, release date: 2005-04-12, Last modification date: 2024-02-14) |
| Primary citation | Wright, S.W.,Rath, V.L.,Genereux, P.E.,Hageman, D.L.,Levy, C.B.,McClure, L.D.,McCoid, S.C.,McPherson, R.K.,Schelhorn, T.M.,Wilder, D.E.,Zavadoski, W.J.,Gibbs, E.M.,Treadway, J.L. 5-Chloroindoloyl glycine amide inhibitors of glycogen phosphorylase: synthesis, in vitro, in vivo, and X-ray crystallographic characterization. Bioorg.Med.Chem.Lett., 15:459-465, 2005 Cited by PubMed Abstract: The synthesis, in vitro, and in vivo biological characterization of a series of achiral 5-chloroindoloyl glycine amide inhibitors of human liver glycogen phosphorylase A are described. Improved potency over previously reported compounds in cellular and in vivo assays was observed. The allosteric binding site of these compounds was shown by X-ray crystallography to be the same as that reported previously for 5-chloroindoloyl norstatine amides. PubMed: 15603973DOI: 10.1016/j.bmcl.2004.10.048 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report
