1XOI

Human Liver Glycogen Phosphorylase A complexed with Chloroindoloyl glycine amide

1XOI の概要

• エントリーDOI: 10.2210/pdb1xoi/pdb
• 関連するPDBエントリー: 1EM6 1EXV
• 分子名称: Glycogen phosphorylase, liver form, N-acetyl-beta-D-glucopyranosylamine, PYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: allosteric enzyme, glycogen storage disease, glycosyltransferase, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 195987.00

構造登録者

Wright, S.W.,Rath, V.L.,Gibbs, E.M.,Treadway, J.L. (登録日: 2004-10-06, 公開日: 2005-04-12, 最終更新日: 2024-02-14)

主引用文献

Wright, S.W.,Rath, V.L.,Genereux, P.E.,Hageman, D.L.,Levy, C.B.,McClure, L.D.,McCoid, S.C.,McPherson, R.K.,Schelhorn, T.M.,Wilder, D.E.,Zavadoski, W.J.,Gibbs, E.M.,Treadway, J.L.
5-Chloroindoloyl glycine amide inhibitors of glycogen phosphorylase: synthesis, in vitro, in vivo, and X-ray crystallographic characterization.
Bioorg.Med.Chem.Lett., 15:459-465, 2005

PubMed Abstract: The synthesis, in vitro, and in vivo biological characterization of a series of achiral 5-chloroindoloyl glycine amide inhibitors of human liver glycogen phosphorylase A are described. Improved potency over previously reported compounds in cellular and in vivo assays was observed. The allosteric binding site of these compounds was shown by X-ray crystallography to be the same as that reported previously for 5-chloroindoloyl norstatine amides.

PubMed: 15603973
DOI: 10.1016/j.bmcl.2004.10.048

実験手法

X-RAY DIFFRACTION (2.1 Å)