1XO3

Solution Structure of Ubiquitin like protein from Mus Musculus

1XO3 の概要

• エントリーDOI: 10.2210/pdb1xo3/pdb
• NMR情報: BMRB: 6337
• 分子名称: RIKEN cDNA 2900073H19 (1 entity in total)
• 機能のキーワード: structural genomics, protein structure initiative, center for eukaryotic structural genomics, psi, cesg, unknown function
• 由来する生物種: Mus musculus (house mouse)
• 細胞内の位置: Cytoplasm (By similarity): Q9D2P4
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11289.90

構造登録者

Singh, S.,Tonelli, M.,Tyler, R.C.,Bahrami, A.,Lee, M.S.,Markley, J.L.,Center for Eukaryotic Structural Genomics (CESG) (登録日: 2004-10-05, 公開日: 2004-10-19, 最終更新日: 2024-05-22)

主引用文献

Singh, S.,Tonelli, M.,Tyler, R.C.,Bahrami, A.,Lee, M.S.,Markley, J.L.
Three-dimensional structure of the AAH26994.1 protein from Mus musculus, a putative eukaryotic Urm1.
Protein Sci., 14:2095-2102, 2005

PubMed Abstract: We have used NMR spectroscopy to determine the solution structure of protein AAH26994.1 from Mus musculus and propose that it represents the first three-dimensional structure of a ubiquitin-related modifier 1 (Urm1) protein. Amino acid sequence comparisons indicate that AAH26994.1 belongs to the Urm1 family of ubiquitin-like modifier proteins. The best characterized member of this family has been shown to be involved in nutrient sensing, invasive growth, and budding in yeast. Proteins in this family have only a weak sequence similarity to ubiquitin, and the structure of AAH26994.1 showed a much closer resemblance to MoaD subunits of molybdopterin synthases (known structures are of three bacterial MoaD proteins with 14%-26% sequence identity to AAH26994.1). The structures of AAH26994.1 and the MoaD proteins each contain the signature ubiquitin secondary structure fold, but all differ from ubiquitin largely in regions outside of this fold. This structural similarity bolsters the hypothesis that ubiquitin and ubiquitin-related proteins evolved from a protein-based sulfide donor system of the molybdopterin synthase type.

PubMed: 16046629
DOI: 10.1110/ps.051577605

実験手法

SOLUTION NMR