1XH5
Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
1XH5 の概要
エントリーDOI | 10.2210/pdb1xh5/pdb |
関連するPDBエントリー | 1SVE 1SVG 1SVH 1VEB 1XH4 1XH6 1XH7 1XH8 1XH9 1XHA |
分子名称 | cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase inhibitor, alpha form, N-{4-[(4-{3-[(2R)-3,3-DIMETHYLPIPERIDIN-2-YL]-2-FLUORO-6-HYDROXYBENZOYL}BENZOYL)AMINO]AZEPAN-3-YL}ISONICOTINAMIDE, ... (5 entities in total) |
機能のキーワード | pka, kinase-inhibitor-complex, serine/threonine-protein kinase, balanol derivative, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Bos taurus (cattle) 詳細 |
細胞内の位置 | Cytoplasm: P00517 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 43790.88 |
構造登録者 | Breitenlechner, C.B.,Friebe, W.-G.,Brunet, E.,Werner, G.,Graul, K.,Thomas, U.,Kuenkele, K.-P.,Schaefer, W.,Gassel, M.,Bossemeyer, D.,Huber, R.,Engh, R.A.,Masjost, B. (登録日: 2004-09-17, 公開日: 2005-09-17, 最終更新日: 2024-06-26) |
主引用文献 | Breitenlechner, C.B.,Friebe, W.-G.,Brunet, E.,Werner, G.,Graul, K.,Thomas, U.,Kuenkele, K.-P.,Schaefer, W.,Gassel, M.,Bossemeyer, D.,Huber, R.,Engh, R.A.,Masjost, B. Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants J.Med.Chem., 48:163-170, 2005 Cited by PubMed: 15634010DOI: 10.1021/jm049701n 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.05 Å) |
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