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1XCW

Acarbose Rearrangement Mechanism Implied by the Kinetic and Structural Analysis of Human Pancreatic alpha-Amylase in Complex with Analogues and Their Elongated Counterparts

Summary for 1XCW
Entry DOI10.2210/pdb1xcw/pdb
Related1XCX 1XD0 1XD1
Related PRD IDPRD_900110
DescriptorAlpha-amylase, 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, CALCIUM ION, ... (6 entities in total)
Functional Keywordsamylase, acarbose, acarbose analogues, inhibitor, acarviosine, isoacarbose, enzyme, catalysis, enzyme mechanism, hydrolase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight56711.51
Authors
Li, C.,Begum, A.,Numao, S.,Park, K.H.,Withers, S.G.,Brayer, G.D. (deposition date: 2004-09-03, release date: 2004-12-07, Last modification date: 2020-07-29)
Primary citationLi, C.,Begum, A.,Numao, S.,Park, K.H.,Withers, S.G.,Brayer, G.D.
Acarbose Rearrangement Mechanism Implied by the Kinetic and Structural Analysis of Human Pancreatic alpha-Amylase in Complex with Analogues and Their Elongated Counterparts
Biochemistry, 44:3347-3357, 2005
Cited by
PubMed: 15736945
DOI: 10.1021/bi048334e
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

217705

数据于2024-03-27公开中

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