1X7X

Crystal structure of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase

1X7X の概要

• エントリーDOI: 10.2210/pdb1x7x/pdb
• 関連するPDBエントリー: 1U5B 1X7W 1X7Y 1X7Z 1X80
• 分子名称: 2-oxoisovalerate dehydrogenase alpha subunit, 2-oxoisovalerate dehydrogenase beta subunit, POTASSIUM ION, ... (8 entities in total)
• 機能のキーワード: oxidoreductase, ketoacid dehydrogenase, branched-chain, multi-enzyme complex, acylation, oxidative decarboxylation maple syrup urine disease, thiamin diphosphate, phosphorylation, flavoprotein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Mitochondrion matrix: P12694 P21953
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 84201.40

構造登録者

Wynn, R.M.,Kato, M.,Machius, M.,Chuang, J.L.,Li, J.,Tomchick, D.R.,Chuang, D.T. (登録日: 2004-08-16, 公開日: 2004-11-23, 最終更新日: 2023-08-23)

• 主引用文献: Wynn, R.M.,Kato, M.,Machius, M.,Chuang, J.L.,Li, J.,Tomchick, D.R.,Chuang, D.T.; Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation; Structure, 12:2185-2196, 2004; PubMed: 15576032; DOI: 10.1016/j.str.2004.09.013

実験手法

X-RAY DIFFRACTION (2.1 Å)