1WVO

Solution structure of RSGI RUH-029, an antifreeze protein like domain in human N-acetylneuraminic acid phosphate synthase gene.

1WVO の概要

• エントリーDOI: 10.2210/pdb1wvo/pdb
• 分子名称: Sialic acid synthase (1 entity in total)
• 機能のキーワード: antifreeze protein like domain, n-acetylneuraminic acid phosphate synthase, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 8269.43

構造登録者

Ito, Y.,Hamada, T.,Hayashi, F.,Yokoyama, S.,Hirota, H.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (登録日: 2004-12-22, 公開日: 2006-01-03, 最終更新日: 2024-05-29)

主引用文献

Hamada, T.,Ito, Y.,Abe, T.,Hayashi, F.,Guntert, P.,Inoue, M.,Kigawa, T.,Terada, T.,Shirouzu, M.,Yoshida, M.,Tanaka, A.,Sugano, S.,Yokoyama, S.,Hirota, H.
Solution structure of the antifreeze-like domain of human sialic acid synthase
Protein Sci., 15:1010-1016, 2006

PubMed Abstract: The structure of the C-terminal antifreeze-like (AFL) domain of human sialic acid synthase was determined by NMR spectroscopy. The structure comprises one alpha- and two single-turn 3(10)-helices and two beta-strands, and is similar to those of the type III antifreeze proteins. Evolutionary trace analyses of the type III antifreeze protein family suggested that the class-specific residues in the human and bacterial AFL domains are important for their substrate binding, while the class-specific residues of the fish antifreeze proteins are gathered on the ice-binding surface.

PubMed: 16597820
DOI: 10.1110/ps.051700406

実験手法

SOLUTION NMR