1WTT

HELIX 45 (16S RRNA) FROM B. STEAROTHERMOPHILUS, NMR, 11 STRUCTURES

1WTT の概要

• エントリーDOI: 10.2210/pdb1wtt/pdb
• 分子名称: RNA (5'-R(*GP*GP*AP*CP*CP*2MGP*GP*MA6P*MA6P*GP*GP*UP*CP*C)-3') (1 entity in total)
• 機能のキーワード: ribonucleic acid, ribosome, rna, 16s, modified nucleotides, tetraloop
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 4610.92

構造登録者

Rife, J.P.,Moore, P.B. (登録日: 1998-06-26, 公開日: 1999-01-27, 最終更新日: 2024-05-22)

主引用文献

Rife, J.P.,Moore, P.B.
The structure of a methylated tetraloop in 16S ribosomal RNA.
Structure, 6:747-756, 1998

PubMed Abstract: Ribosomal RNAs contain many modified nucleotides. The functions of these nucleotides are poorly understood and few of them are strongly conserved. The final stem loop in 16S-like rRNAs is an exception in both regards. In both prokaryotes and eukaryotes, the tetranucleotide loop that caps the 3'-terminal stem contains two N6, N6-dimethyladenosine residues. The sequence and pattern of methylation are conserved within the loop, and there is evidence that these methylated nucleotides play an important role in subunit association and the initiation of protein synthesis. Because of the integral role that helix 45 plays in ribosome function, it is important to know what consequences these methylated nucleotides have on its structure.

PubMed: 9655826
DOI: 10.1016/S0969-2126(98)00076-8

実験手法

SOLUTION NMR