1WOF

Crystal Structure Of SARS-CoV Mpro in Complex with an Inhibitor N1

Summary for 1WOF

• Entry DOI: 10.2210/pdb1wof/pdb
• Related: 1UJ1 1WNO
• Descriptor: 3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]-L-ALANYL-L-VALYL-N~1~-((1S)-4-ETHOXY-4-OXO-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE (3 entities in total)
• Functional Keywords: anti-parallel b-barrel, anti-parallel a-helices, hydrolase
• Biological source: SARS coronavirus
• Cellular location: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity): P59641
• Total number of polymer chains: 2
• Total formula weight: 69813.62

Authors

Yang, H.,Bartlam, M.,Xue, X.,Yang, K.,Liang, W.,Rao, Z. (deposition date: 2004-08-18, release date: 2005-08-30, Last modification date: 2011-07-13)

• Primary citation: Yang, H.,Xie, W.,Xue, X.,Yang, K.,Ma, J.,Liang, W.,Zhao, Q.,Zhou, Z.,Pei, D.,Ziebuhr, J.,Hilgenfeld, R.,Yuen, K.Y.,Wong, L.,Gao, G.,Chen, S.,Chen, Z.,Ma, D.,Bartlam, M.,Rao, Z.; Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.; Plos Biol., 3:324-334, 2005; PubMed: 16128623; DOI: 10.1371/journal.pbio.0030324

Experimental method

X-RAY DIFFRACTION (2 Å)