1WOF
Crystal Structure Of SARS-CoV Mpro in Complex with an Inhibitor N1
Summary for 1WOF
Entry DOI | 10.2210/pdb1wof/pdb |
Related | 1UJ1 1WNO |
Descriptor | 3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]-L-ALANYL-L-VALYL-N~1~-((1S)-4-ETHOXY-4-OXO-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE (3 entities in total) |
Functional Keywords | anti-parallel b-barrel, anti-parallel a-helices, hydrolase |
Biological source | SARS coronavirus |
Cellular location | Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity): P59641 |
Total number of polymer chains | 2 |
Total formula weight | 69813.62 |
Authors | |
Primary citation | Yang, H.,Xie, W.,Xue, X.,Yang, K.,Ma, J.,Liang, W.,Zhao, Q.,Zhou, Z.,Pei, D.,Ziebuhr, J.,Hilgenfeld, R.,Yuen, K.Y.,Wong, L.,Gao, G.,Chen, S.,Chen, Z.,Ma, D.,Bartlam, M.,Rao, Z. Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases. Plos Biol., 3:324-334, 2005 Cited by PubMed: 16128623DOI: 10.1371/journal.pbio.0030324 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report