1WO9

Selective inhibition of trypsins by insect peptides: role of P6-P10 loop

1WO9 の概要

• エントリーDOI: 10.2210/pdb1wo9/pdb
• 分子名称: trypsin inhibitor (1 entity in total)
• 機能のキーワード: hydrolase inhibitor
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3727.26

構造登録者

Kellenberger, C.,Ferrat, G.,Leone, P.,Darbon, H.,Roussel, A. (登録日: 2004-08-12, 公開日: 2004-09-07, 最終更新日: 2024-10-30)

主引用文献

Kellenberger, C.,Ferrat, G.,Leone, P.,Darbon, H.,Roussel, A.
Selective inhibition of trypsins by insect peptides: role of P6-P10 loop
Biochemistry, 42:13605-13612, 2003

PubMed Abstract: PMP-D2 and HI, two peptides from Locusta migratoria, were shown to belong to the family of tight-binding protease inhibitors. However, they interact weakly with bovine trypsin (K(i) around 100 nM) despite a trypsin-specific Arg at the primary specificity site P1. Here we demonstrate that they are potent inhibitors of midgut trypsins isolated from the same insect and of a fungal trypsin from Fusarium oxysporum (K(i) PubMed: 14622007
DOI: 10.1021/bi035318t

実験手法

SOLUTION NMR